Lifestyle

A live biotherapeutic product reduces lung damage in a neonatal mouse model of chronic lung disease

Two factors contribute to the lung disease bronchopulmonary dysplasia, or BPD, in extremely premature infants: the high oxygen concentrations that premature infants need to aid their breathing and a microbial dysbiosis in the lungs after birth. Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have previously shown that a microbiome is present […]

Lifestyle

Neutrophils overcome their inability to swarm by cooperatively generating LTB4 through transcellular biosynthesis

Bryan Hurley, Ph.D., an associate investigator in the Mucosal Immunology and Biology Research Center at Mass General for Children and an associate professor of pediatrics at Harvard Medical School and Daniel Irimia, MD, Ph.D., of the Center for Engineering in Medicine and Surgery at Massachusetts General Hospital and an associate professor of surgery at Harvard […]

Lifestyle

The hunt for disrupted brain signals behind autism

Part of understanding the underlying causes of autism spectrum disorder relies on figuring out which cells’ signaling patterns in the brain are disrupted, and when during nervous system development the disruption occurs. New research findings in mouse models of one genetic risk for autism support the idea that loss of a specific gene interferes with […]

Lifestyle

Unexpected electrical changes seen in first successful transplant of genetically-modified pig heart

Ten months after transplanting the first genetically-modified pig heart into a human patient, University of Maryland School of Medicine (UMSOM) researchers continue to report on new findings from the landmark transplant. Their latest study, published in Circulation demonstrates for the first time that unexpected electrical changes occurred in the pig heart transplanted into the patient […]

Lifestyle

Researchers show liquid biopsies can catch disease progression early in high-risk neuroblastoma

Neuroblastoma is an aggressive pediatric cancer that develops from early nerve cells and accounts for up to 10% of childhood cancer deaths. Survival rates are low—less than 50% of patients with the disease survive, and less than 5% with relapsed disease overcome it. One challenge researchers face is monitoring how the cancer mutates in response […]

Lifestyle

Morning physical activity is associated with the lowest risk of heart disease and stroke

Morning physical activity is associated with the lowest risk of heart disease and stroke, according to a study in more than 85,000 individuals published today in the European Journal of Preventive Cardiology. The findings were consistent regardless of the total amount of daily activity. “It is well established that exercise is good for heart health, […]

Lifestyle

Researchers create novel device to measure nerve activity for treatment of sepsis and PTSD

A multi-campus research team has developed a novel device for non-invasively measuring cervical nerve activity in humans. The device, described in an article in Scientific Reports, has potential applications for supporting more personalized treatments for sepsis and mental health conditions such as post-traumatic stress disorder (PTSD). “With this newly developed device we (for the first […]